We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac threat elements utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, probably secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the proper coronary artery. Physicians and patients should be conscious of the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.

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• Moreover, testosterone has been used within the remedy of reduced muscle mass and bone density in addition to anemia.
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However, testosterone in physiologic doses might even be useful in sufferers with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in men with established coronary artery disease . Therefore, an interplay of endogenous factors of the patient’s risk profile as properly as the testosterone dosing could also be problems with whether or not antagonistic occasions happen. Erythrocytosis has been reported as a possible impact of testosterone, which could be beneficial in patients with anemia. The best risk of erythrocytosis happens with injectable types of testosterone compared with transdermal preparations, particularly in supraphysiologic doses. An enhance of up to 44% of the baseline hematocrit has been reported .

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Moreover, testosterone has been used in the therapy of lowered muscle mass and bone density as well as anemia. The role testosterone could play in the improvement of cardiovascular disease has increasingly turn into the subject of present interest . Anabolic androgenic steroid use has elevated over the previous decade, despite its potential for adverse results. They proceed for use by Olympic level athletes, and have even spread to high school level athletes, noncompetitive bodybuilders and recreational athletes (Sullivan et al 1998; Dhar et al 2007).

Unfortunately, the info on the utilization of excessive dose anabolic steroids in humans are mainly offered as case reports or small research that lack adequate control teams. In addition, the info obtainable in the literature doesn’t account for the steroid kind or dose, as neither could also be known. Patients additionally may be taking concomitant stimulants, similar to ephedra, which can confound knowledge and the potential for antagonistic events. It is in all probability going that the frequency of cardiac events is underreported within the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embrace greater than 30 pure and synthetic derivatives of testosterone, might cause a wide spectrum of medical sequalae.

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